Sodium ion batteries (SIBs) for large-scale grid applications are facing great challenges in development of high-performance electrode materials and screening of suitable electrolytes. Herein, a versatile and scalable protocol of synthesizing two-dimensional (2D) holey cobalt sulfide (h-Co4S3) nanosheets is demonstrated for high-rate and long-life SIBs in an ether-based electrolyte of 1.0 M NaCF3SO3 in diglyme. The 2D h-Co4S3 nanosheets is prepared by sulfuration of leaf-like cobalt based metal-organic frameworks (CoMOFs), and subsequent annealing treatment. Benefiting from the nanosheet nature of holey nanopores (10-30 nm), ultra-thinness (<30 nm), crumpled morphology, and micron lateral size that can provide enriched active sites and enhanced sodiation/desodiation kinetics, the resulting h-Co4S3 nanosheets achieves high reversible capacity of 571 mA h g−1 at 0.1 A g−1, and long-life cycling stability with retention of 80% after 400 times for SIBs. Furthermore, theoretical simulation elucidates the enhance structure stability of h-Co4S3 nanosheets with lower binding energy (0.31 eV) of Co-O bond in ether-based electrolyte than that in carbonate-based electrolyte. Notably, h-Co4S3 anode offeres exceptional rate capacity of 257 mAh g−1 at 12 A g−1, outperforming most reported cobalt sulfide–based anodes. This strategy will pave a new way to rationally construct MOFs-derived 2D nanostructures for various energy-related applications.